Can i take excedrin with paxlovid - Plus, there are potential downsides: Paxlovid can clash with many medications and it can cause some side effects, including a particularly weird one. If you are thinking about taking Paxlovid ...

 
Your doctor will determine if you can stay off any interacting drugs for 5 days or possibly take a lower dose of certain drugs while on Paxlovid. Who can get Paxlovid? In the U.S., not every COVID .... Cz p10m extended magazine

Applies to: Prozac (fluoxetine) and Paxlovid (nirmatrelvir / ritonavir) Using FLUoxetine together with ritonavir may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, or if your condition worsens. If your doctor does prescribe these ...However, another component of Paxlovid, ritonavir, can negatively interact with anti-rejection medications taken by immunocompromised people, most notably …Home. Paxlovid. FAQ. Paxlovid side effects: 8 key things to know. Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 6, 2023. Official …An editorial published in the Clinical Journal of the American Society of Nephrology suggests use of low-dose Paxlovid regimens may be feasible in advanced CKD. According to the FDA’s Paxlovid emergency use authorization (EAU), the standard dose is 300 mg nirmatrelvir (two 150 mg tablets) and 100 mg ritonavir (one 100 mg …Who can take Paxlovid? Paxlovid can be taken by people who are 12 years or older and weigh at least 88 pounds. Paxlovid is authorized for people who have mild to moderate COVID-19 and are at risk of developing severe symptoms that could lead to hospitalization or death.(Paxlovid) is efficacious in preventing hospitalization and death,1 and the Food and Drug Administration has granted emergency use authorization for this purpose.2 Ritonavir increases plasma concentrations of nirmatrelvir by inhibiting cytochrome P450 (CYP) 3A4. CYP 3A4 inhibition confers an increased risk of drug-drug interactions with Famotidine is in the drug class H2 antagonists . Famotidine is used to treat the following conditions: Allergic Urticaria (off-label) Cutaneous Mastocytosis. Duodenal Ulcer. Duodenal Ulcer Prophylaxis. Erosive Esophagitis. GERD. Hiatal Hernia (off-label) carBAMazepine ritonavir. Applies to: carbamazepine and Paxlovid (nirmatrelvir / ritonavir) Using carBAMazepine together with ritonavir may increase the effects of carBAMazepine. Contact your doctor if you experience shallow breathing, fast heartbeat, nausea, vomiting, urinating less or not at all, muscle twitches, restlessness, tremors, slurred ...Omeprazole is in the drug class proton pump inhibitors . Omeprazole is used to treat the following conditions: Barrett's Esophagus. Duodenal Ulcer. Erosive Esophagitis. Gastritis/Duodenitis (off-label) GERD. Helicobacter Pylori Infection. Hiatal Hernia (off-label)It's important that you start taking Paxlovid within 5 days (or 7 days, if advised by a healthcare professional) of getting COVID-19 symptoms. Swallow the tablets whole with a drink of water. Do not chew, break or crush the tablets. You can take them with or without food. Take one dose of 3 tablets in the morning and one dose of 3 tablets in ...Joe Sugarman, the highly successful entrepreneur who was best known for his legendary BluBlocker Sunglasses, has died at the age of 83. Joe Sugarman, the highly successful entrepre...It can help lower the risk of hospitalization and death from COVID-19. But, it has many interactions to be aware of. One possible interaction is with corticosteroids like methylprednisolone. Paxlovid can …ritonavir clopidogrel. Applies to: Paxlovid (nirmatrelvir / ritonavir) and clopidogrel. Ritonavir may interfere with the blood thinning effects of clopidogrel in some patients. This may make the medication less effective in preventing blood clots, heart attacks, and strokes. Talk to your doctor if you have any questions or concerns.Nirmatrelvir is an oral protease inhibitor that is active against M PRO, a viral protease that plays an essential role in viral replication by cleaving the 2 viral polyproteins. 1 It has demonstrated antiviral activity …amphetamine ritonavir. Applies to: Adderall (amphetamine / dextroamphetamine) and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may increase the blood levels and effects of amphetamine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you ...Paxlovid Expiration Dates Extended. Expiration dates have been extended from 9 months after manufacture to 12 months for 4 lots of the COVID-19 antiviral therapy Paxlovid, which consists of copackaged nirmatrelvir tablets and ritonavir tablets. The lot numbers and original expiration dates are listed on the FDA website.6. In principle, the risk of interactions considering the profile of the drug and Paxlovid is probably very low. In any case, the combination of should be performed considering the general precautions of any combination. 7. Risk of increased Paxlovid concentrations due to increased absorption from reduced first pass in the gut. … No. Paxlovid is only authorized for patients who are 12 years or older who weigh more than 40 kg (88 lbs). Children under 12, or children 12 or older who weigh less than 88 lbs, cannot receive Paxlovid. In addition, only children with underlying medical conditions that place them at high risk for severe COVID-19 infection can receive Paxlovid. If you haven't subscribed yet, you can do that by ... In B.C. alone, roughly 300 people each week take Paxlovid, according to data cited by UBC's Therapeutics …Oral ritonavir-boosted nirmatrelvir (Paxlovid) In a clinical trial, ritonavir-boosted nirmatrelvir reduced the risk of hospitalization and death by 86% in unvaccinated outpatients with COVID-19 at higher risk of severe disease. Serious adverse events are uncommon with Paxlovid treatment.A. Cardiovascular disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications, according to a review paper published Oct. 12 in JACC. Specifically, the paper examines the potential drug-drug ...Paxlovid is a drug regimen developed by Pfizer for people 12 and older who have mild to moderate COVID-19 and are at high risk of becoming severely sick or dying, per the FDA fact sheet (PDF ...The top 3 most common but usually temporary side effects with Paxlovid are a bitter or metallic taste, diarrhea and an increase in blood pressure. Important but less common side effects or warnings can include severe allergies, liver problems and a build up of resistance to HIV medicines.Get treated for COVID-19 or flu. We’ll walk you through the process to help you get the COVID-19 or flu treatment you may need from a licensed CVS® pharmacist. If you’re not sure which treatment would be right for you, you can take our pre-treatment survey to help you decide on your next steps. Take our pre-treatment survey.Applies to: Paxlovid (nirmatrelvir / ritonavir) and mirtazapine. Ritonavir may increase the blood levels of mirtazapine in some patients. This can increase the risk and/or severity of side effects such as dizziness, drowsiness, restlessness, confusion, difficulty concentrating, impairment in thinking and judgment, dry mouth, constipation, low ...Paxlovid. A total of 665 drugs are known to interact with Paxlovid. Paxlovid is in the drug class antiviral combinations. Paxlovid is used to treat COVID-19. Vitamin D3. A total of 72 drugs are known to interact with Vitamin D3. Vitamin d3 is in the drug class vitamins.Under new rules just issued by the Food and Drug Administration (FDA), you no longer need a positive COVID-19 test to get a prescription for Paxlovid, an antiviral drug that treats the virus. The FDA revised the emergency use authorization (EUA) for both Paxlovid and Lagevrio on Wednesday. Fact sheets regarding the updated EUA note a …A Chinese take-out family favorite, this Sweet & Sour Chicken cuts out the sugar and fat of restaurant varieties. This version combines the natural sweetness of pineapples with Spl...A. Cardiovascular disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications, according to a review paper published Oct. 12 in JACC. Specifically, the paper examines the potential drug …Mixing Paxlovid with herbal remedies and supplements. Do not take St John's wort, the herbal remedy for depression, while you are being treated with Paxlovid. This is because it may make your course of treatment less effective. There is not enough information to say that other herbal remedies or supplements are safe to take with Paxlovid.propranolol ritonavir. Applies to: propranolol and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may increase the blood levels and effects of propranolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.Applies to: cetirizine and Paxlovid (nirmatrelvir / ritonavir) Using cetirizine together with ritonavir may increase the effects of cetirizine. Cetirizine effects may be increased during …Diarrhea with Paxlovid was infrequently reported in studies, occurring in 3% of people taking Paxlovid and 2% of people taking a placebo (an inactive pill). If you have diarrhea with this treatment, be sure to drink plenty of fluids to replace those you may be losing. Avoid any foods that may upset your stomach, like spicy, fried or fatty foods.ritonavir tamsulosin. Applies to: Paxlovid (nirmatrelvir / ritonavir) and tamsulosin. Using tamsulosin together with ritonavir is not recommended. Combining these medications may significantly increase the blood levels and effects of tamsulosin. This may cause blood pressure to fall excessively and heart rate to increase, especially when you ...Officially, there are seven potential Paxlovid side effects listed by the FDA that your care provider should make you aware of: Liver problems. Allergic reactions. Muscle aches or pains. High ...propranolol ritonavir. Applies to: propranolol and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may increase the blood levels and effects of propranolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.Applies to: simvastatin and Paxlovid (nirmatrelvir / ritonavir) Using simvastatin together with ritonavir is not recommended. Combining these medications may significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves ...The Paxlovid dose for people with mild to moderate kidney problems is 150 mg (1 tablet) of nirmatrelvir and 100 mg (1 tablet) of ritonavir by mouth every 12 hours for 5 days. This medication isn’t recommended for people with severe kidney or liver problems. You can take Paxlovid with or without food. But the tablets should be swallowed whole.Paxlovid, an antiviral treatment for people at high risk of severe disease who have mild to moderate cases of COVID-19, is effective against the latest COVID-19 variant. Experts recommend that...Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Unknown: No interaction information available. Further information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Your healthcare provider will determine if you can safely take ondansetron if you’re taking an SNRI or SSRI. 3. Other medications that affect serotonin. Besides SSRIs and SNRIs, other medications can also affect serotonin. Combining these medications with ondansetron can raise the risk of serotonin syndrome. Examples of these medications …Dec 5, 2023 · Experts say that medications that can be used to treat mild to moderate COVID symptoms include over-the-counter (OTC) drugs like Tylenol and Advil, as well as prescription medications like Paxlovid and Lagevrio. Other than taking medications, recovering from COVID at home involves staying hydrated and getting plenty of rest. The Food and Drug Administration (FDA) prescribing information includes a boxed warning about significant drug-drug interactions between ritonavir-boosted nirmatrelvir (Paxlovid) and other medications.[Originally published: Oct. 9, 2023. Updated: April 15, 2024] Paxlovid is a pill that has proven to be effective at preventing severe disease from COVID-19.You start taking Paxlovid pills within the first five days of experiencing COVID symptoms (if you are 12 or older and at risk for serious disease), and it can protect you from getting so sick you need to be hospitalized.It's important that you start taking Paxlovid within 5 days (or 7 days, if advised by a healthcare professional) of getting COVID-19 symptoms. Swallow the tablets whole with a drink of water. Do not chew, break or crush the tablets. You can take them with or without food. Take one dose of 3 tablets in the morning and one dose of 3 tablets in ...Paxlovid can stop combined oral contraceptive pills ("the pill") from working properly. If you are taking Paxlovid it's important to use effective contraception (a condom, female condom, diaphragm or cap) for the full 5 days of treatment and until you've had one full menstrual cycle.Potential Paxlovid side effect: Metallic taste in mouth. Paxlovid's primary side effect is a metallic taste in the mouth during the five days of treatment. It goes away at the end. "The side ...Paxlovid is a drug regimen developed by Pfizer for people 12 and older who have mild to moderate COVID-19 and are at high risk of becoming severely sick or dying, per the FDA fact sheet (PDF ...Paxlovid is contraindicated in patients taking any CYP3A4 inducing agent as these medications significantly decrease the concentration of Paxlovid and thus decrease its effectiveness. Holding the interacting medicines is not an option as the enzyme induction effect does not immediately dissipate when a medication is stopped.Smart speakers, lights, virtual assistants, and more. By clicking "TRY IT", I agree to receive newsletters and promotions from Money and its partners. I agree to Money's Terms of U...Some of the possible side effects of Paxlovid include the following: Allergic reactions. Liver problems. Resistance to HIV medicines. Diarrhea. Muscle aches. Altered sense of taste. High blood pressure. There are anecdotal reports of people experiencing a relapse of COVID-19 symptoms after taking Paxlovid.Jan 19, 2023 · A few months earlier, a study out of Israel had confirmed the efficacy of Paxlovid — the brand name for a combination of nirmatrelvir and ritonavir — in seniors infected with COVID’s omicron... Applies to: oxycodone and Paxlovid (nirmatrelvir / ritonavir) Ritonavir can increase the blood levels and effects of oxyCODONE. Contact your doctor if you experience dizziness, fainting, confusion, excessive drowsiness, slow heart rate, shallow or difficult breathing, and/or shortness of breath. You may need a dose adjustment or more frequent ...Applies to: Dilantin (phenytoin) and Paxlovid (nirmatrelvir / ritonavir) Using nirmatrelvir together with phenytoin is not recommended. Combining these medications may significantly reduce the blood levels of nirmatrelvir, which may make it less effective in treating COVID-19 infection. Talk to your doctor if you have any questions or concerns.Because ritonavir-boosted nirmatrelvir is the only highly effective oral antiviral for the treatment of COVID-19, drug interactions that can be safely managed should not preclude the use of this medication. Box 1. Select Outpatient Medications Not Expected to Have Clinically Relevant Interactions With Ritonavir-Boosted Nirmatrelvir (Paxlovid ...This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. With certain long-acting formulations of narcotic pain medication, consumption of ...PAXLOVID can interact with other medicines causing severe or life-threatening side effects or death. It is very important to tell your healthcare provider …Paxlovid (nirmatrelvir / ritonavir) is a first-choice treatment option for mild to moderate COVID-19. Many people notice that Paxlovid starts relieving symptoms in about 1 to 2 days. But it often takes about 2 to 4 days for symptoms to fully resolve. Recent studies show that Paxlovid is about 37% effective in preventing hospitalization and ...However, another component of Paxlovid, ritonavir, can negatively interact with anti-rejection medications taken by immunocompromised people, most notably …Applies to: Prozac (fluoxetine) and Paxlovid (nirmatrelvir / ritonavir) Using FLUoxetine together with ritonavir may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, or if your condition worsens. If your doctor does prescribe these ... cetirizine ritonavir. Applies to: cetirizine and Paxlovid (nirmatrelvir / ritonavir) Using cetirizine together with ritonavir may increase the effects of cetirizine. Cetirizine effects may be increased during administration with ritonavir, particularly in the elderly and or if you have kidney impairment. Contact your doctor if you experience ... Applies to: estradiol and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may reduce the blood levels and effects of estradiol. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring ...Now, ritonavir can cause transaminase liver function test elevations and Paxlovid is not recommended for patients with severe hepatic impairment. For those managing patients with uncontrolled HIV infection, so these are HIV patients who do not have an undetectable viral load, Paxlovid use could lead to development of protease …Applies to: Prozac (fluoxetine) and Paxlovid (nirmatrelvir / ritonavir) Using FLUoxetine together with ritonavir may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, or if your condition worsens. If your doctor does prescribe these ...Your healthcare provider will determine if you can safely take ondansetron if you’re taking an SNRI or SSRI. 3. Other medications that affect serotonin. Besides SSRIs and SNRIs, other medications can also affect serotonin. Combining these medications with ondansetron can raise the risk of serotonin syndrome. Examples of these medications include:Under new rules just issued by the Food and Drug Administration (FDA), you no longer need a positive COVID-19 test to get a prescription for Paxlovid, an antiviral drug that treats the virus. The FDA revised the emergency use authorization (EUA) for both Paxlovid and Lagevrio on Wednesday. Fact sheets regarding the updated EUA note a …warfarin ritonavir. Applies to: warfarin and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may both increase or decrease the blood levels and effects of warfarin. Early in your treatment with ritonavir, the interaction may be more unpredictable. However, beyond the first week or so of continued use, it is more common for patients to experience ...Related/similar drugs Lagevrio, remdesivir, molnupiravir, Actemra, nirmatrelvir / ritonavir, tocilizumab Paxlovid rebound and COVID-19 rebound. COVID-19 rebound is when COVID-19 symptoms return between 2 and 8 days after initial COVID-19 recovery, this can happen in some people that are in vaccinated, unvaccinated, Paxlovid treated and people who have not been treated with Paxlovid.metoprolol ritonavir. Applies to: metoprolol and Paxlovid (nirmatrelvir / ritonavir) Ritonavir may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.Key Takeaways. “Paxlovid mouth” is the lingering bad taste that some people get while they are taking the antiviral drug Paxlovid for a COVID-19 infection. The taste may last for the duration of Paxlovid treatment—five days—and has been described as bitter or metallic. Some people who have experienced Paxlovid mouth say that it goes ...PAXLOVID can interact with other medicines causing severe or life-threatening side effects or death. It is very important to tell your healthcare provider …(Paxlovid) is efficacious in preventing hospitalization and death,1 and the Food and Drug Administration has granted emergency use authorization for this purpose.2 Ritonavir increases plasma concentrations of nirmatrelvir by inhibiting cytochrome P450 (CYP) 3A4. CYP 3A4 inhibition confers an increased risk of drug-drug interactions withThe FDA has authorized Pfizer’s Paxlovid for emergency use* to treat COVID-19 patients at high risk of hospitalization or death. Paxlovid can slow the replication of the virus that causes COVID, but it has the potential for dangerous interactions with drugs commonly prescribed for diabetes, heart disease, and many other conditions.Lagevrio (molnupiravir) and Paxlovid (nirmatrelvir and ritonavir) are prescription medications used to treat COVID-19. Though both have similar uses, they differ in several ways. Lagevrio is available under the Food and Drug Administration's (FDA) emergency use authorization (EUA). Paxlovid, on the other hand, has received full approval from ...The Wood Magnet from Swanson Tools is level that attaches directly to any standard 2-inch lumber to make plumbing and leveling easy. Expert Advice On Improving Your Home Videos Lat...Applies to: Paxlovid (nirmatrelvir / ritonavir) and melatonin. Ritonavir may decrease the blood levels and effects of melatonin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications.(Paxlovid) is efficacious in preventing hospitalization and death,1 and the Food and Drug Administration has granted emergency use authorization for this purpose. 2 Ritonavir increases plasma concentrations of nirmatrelvir by inhibiting cytochrome P450 ritonavir food. Applies to: Paxlovid (nirmatrelvir / ritonavir) Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor. Switch to professional interaction data. levothyroxine ritonavir. Applies to: levothyroxine and Paxlovid (nirmatrelvir / ritonavir) Using ritonavir together with levothyroxine may decrease the effects of levothyroxine. Contact your doctor if you experience tiredness sluggishness, weakness, memory problems, depression, difficulty concentrating, and constipation.If the patient misses a dose by more than 8 hours, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. The patient should not double the dose to make up for a missed dose. PAXLOVID (both nirmatrelvir and ritonavir tablets) can be taken with or without food [see Clinical Pharmacology (12.3 ...Applies to: simvastatin and Paxlovid (nirmatrelvir / ritonavir) Using simvastatin together with ritonavir is not recommended. Combining these medications may significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves ...

Paxlovid. A total of 665 drugs are known to interact with Paxlovid. Paxlovid is in the drug class antiviral combinations. Paxlovid is used to treat COVID-19. Vitamin B12. A total of 15 drugs are known to interact with Vitamin B12. Vitamin b12 is in the drug class vitamins.. Mbta ct3

can i take excedrin with paxlovid

Officially, there are seven potential Paxlovid side effects listed by the FDA that your care provider should make you aware of: Liver problems. Allergic reactions. Muscle aches or pains. High ...ritonavir ivermectin. Applies to: Paxlovid (nirmatrelvir / ritonavir) and ivermectin. Ritonavir may increase the blood levels and effects of ivermectin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.Applies to: Paxlovid (nirmatrelvir / ritonavir) and Ozempic (semaglutide) Ritonavir may interfere with blood glucose control and reduce the effectiveness of semaglutide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with ritonavir.Applies to: Paxlovid (nirmatrelvir / ritonavir) and azelastine / fluticasone nasal. Talk to your doctor before using ritonavir together with fluticasone nasal. Combining these medications may increase the absorption of fluticasone nasal into the blood stream. You may be more likely to experience side effects such as swelling, weight gain, high ...Your healthcare provider will determine if you can safely take ondansetron if you’re taking an SNRI or SSRI. 3. Other medications that affect serotonin. Besides SSRIs and SNRIs, other medications can also affect serotonin. Combining these medications with ondansetron can raise the risk of serotonin syndrome. Examples of these medications …About 10% of patients can’t take Paxlovid because of potential drug interactions, according to Dr. Scott Dryden-Peterson, medical director of COVID outpatient therapy for Mass General Brigham.A few months earlier, a study out of Israel had confirmed the efficacy of Paxlovid — the brand name for a combination of nirmatrelvir and ritonavir — in seniors infected with COVID’s omicron...The biggest downside with Paxlovid is that it can cause serious side effects if combined with many commonly used drugs for a wide range of other conditions. In some cases, people taking these ...Feb 22, 2023 · Paxlovid is the first-choice treatment for mild to moderate COVID in people with a higher risk of severe illness. In initial clinical studies, it was about 90% effective at preventing COVID-related hospitalization and death. While serious side effects are rare, Paxlovid can cause a bitter or bad taste in your mouth while you’re taking it. Acetaminophen, ibuprofen, and naproxen can all be used for pain relief from COVID-19 body aches. Acetaminophen ( Tylenol ), ibuprofen ( Advil, Motrin ), and naproxen ( Aleve) can all be used for pain relief from COVID-19 body aches if they are taken in the recommended doses and approved by your doctor. Early on in the pandemic, the World …LVIP JPMORGAN HIGH YIELD FUND SERVICE CLASS- Performance charts including intraday, historical charts and prices and keydata. Indices Commodities Currencies StocksPaxlovid is intended for people with mild or moderate symptoms. “Take it as early as possible, to nip it in the bud and prevent yourself from being so sick,” Dr. Al-Aly said. Even if you ....

Popular Topics